| 姓名：张前 |
职称/职务：副教授 |
电话： |
传真： |
电子信箱：zhangqian154@snnu.edu.cn |
研究方向：针对神经炎症及脱髓鞘相关疾病的药物筛选及机制研究；中药药效物质基础 |
办公地点： |
一、个人简介
张前，副教授，硕士研究生导师。本科及硕士就读于西北大学生命科学学院，博士毕业于上海中医药大学中药研究所。2013-2020年任职于西安交通大学附属红会医院转化医学中心，2021年至今任职于陕西师范大学生命科学学院。
主持国家自然科学基金2项，省自然科学基金2项，省中医药管理局项目1项，中央高校科研项目1项，参与多项国家级、省级课题。发表第一/通讯作者SCI论文十余篇。担任Neural Regeneration Research, Phytomedicine, Phytotherapy Research等杂志审稿人。
二、主要研究领域及兴趣
1. 针对神经炎症及脱髓鞘相关疾病的药物筛选及机制研究。
2. 中药药效物质基础。
三、承担的科研项目
1. 国家自然科学基金面上项目，82474145，基于神经-免疫-内分泌调节途径探究黄芩汤改善多发性硬化症的作用机制及物质基础，2025.1.1-2028.12.31，主持。
2. 陕西省自然科学基金重点项目，2022JZ-46，针对脊髓损伤的黄芩“清热燥湿”效应成分辨识及作用机制研究，2022.1.1-2024.12.31，主持。
3. 中央高校基本科研业务费一般项目，GK202103079，黄芩苷通过IKK/NF-κB通路干预脊髓损伤后炎症及凋亡的机制研究，2021.1.1-2022.12.31，主持。
4. 陕西省自然科学基金面上项目，2017JM8058，丹参-黄芩对大鼠脊髓损伤后血-脊髓屏障的保护作用及其机制研究，2017.1.1-2018.12.31，主持。
5. 陕西省中医药管理局项目，15-ZY038，丹参、黄芩联合治疗大鼠脊髓损伤的配伍规律及合理性研究，2016.1.1-2017.12.31，主持。
6. 国家自然科学基金青年项目，81403278，丹参-黄芩干预大鼠脊髓损伤后早期炎症反应的作用机制及物质基础研究，2015.1.1-2017.12.31，主持。
四、代表性论文
1. Yufang Lu#, Ruiying Zhou#, Ruyi Zhu, Xue Wu, Jin Liu, Yue Ma, Xin Zhang, Yaling Zhang, Luting Yang, Yanhua Li, Yuan Zhang, Yaping Yan*, Qian Zhang*. Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway. Neuropharmacology, 2025, 267:110296.
2. Ruyi Zhu, Yaling Zhang, Weitai He, Yanan Sun, Xin Zhao, Yaping Yan*, Qian Zhang*. European Journal of Pharmacology-Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF-κB signaling axis after spinal cord injury. European Journal of Pharmacology, 2024, 973:176566.
3. Rui Zhao#, Xue Wu#, Xue-Yuan Bi, Hao Yang, Qian Zhang*. Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury. Neural Regeneration Research, 2022, 17(5): 1080-1087.
4. Xue Wu, Yaping Yan, Qian Zhang*. Neuroinflammation and modulation role of natural products after spinal cord injury, Journal of Inflammation Research, 2021, 14: 5713-5737.
5. Rui Zhao, Xifang Liu, Lixin Zhang, Hao Yang, Qian Zhang*. Current Progress of Research on Neurodegenerative Diseases of Salvianolic acid B. Oxidative Medicine and Cellular Longevity. 2019, 3281260.
6. Qian Zhang*, Xifang Liu, Liang Yan, Rui Zhao, Jing An, Ciucui Liu, Hao Yang. Danshen extract (Salvia miltiorrhiza Bunge) attenuate spinal cord injury in a rat model: a metabolomic approach for the mechanism study. Phytomedicine. 2019, 62, 152966.
7. Lixin Zhang, Xifang Liu, Hao Yang, Rui Zhao, Cuicui Liu, Rui Zhang, Qian Zhang*. Comparative pharmacokinetic study on phenolic acids and flavonoids in spinal cord injury rats plasma by UPLC-MS/MS after single and combined oral administration of danshen and huangqin extract. Journal of Pharmaceutical and Biomedical Analysis. 2019, 172: 103-112.
8. Qian Zhang*, Li-Xin Zhang, Jing An, Liang Yan, Cui-Cui Liu, Jing-Jing Zhao, Hao Yang*. Huangqin flavonoid extraction for spinal cord injury in a rat model. Neural Regeneration Research. 2018, 13(12): 2200-2208.
9. Qian Zhang, Yueming Ma, Zhengtao Wang, Changhong Wang*. Pharmacokinetics difference of multiple active constituents from decoction and maceration of Fuzi Xiexin Tang after oral administration in rat by UPLC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 2014, 92: 35-46.
10. Qian Zhang, Changhong Wang, Yueming Ma, Zhengtao Wang*. Difference in pharmacokinetics and anti-inflammatory effect between decoction and maceration of Sanhuang Xiexin Tang in rats and mice. Planta Medica. 2013, 79(17): 1666-1673.
