崔婷婷

一、个人简介

崔婷婷，博士，副研究员，硕士生导师。主要从事视神经脊髓炎谱系疾病（NMOSD）的发病机制及实验治疗研究。相关成果发表于PNAS、Nature Communications、Cell Reports等国际权威杂志。主持国家自然科学基金青年项目及陕西省青年科学基金项目，作为核心成员参与国家自然科学基金区域联合重点项目等项目4项，作为主要完成人参与横向课题2项。现任陕西省国际医学交流促进会神经免疫专业委员会委员，中国神经科学学会胶质细胞分会会员。

教育及工作经历

2026.07至今 陕西师范大学生命科学学院 副研究员

2025.07-2026.07 陕西师范大学 博士后

2018.09-2025.07 陕西师范大学 细胞生物学 硕博连读

2010.09-2014.07 兰州大学 生物技术基地班 本科

二、主要研究领域及兴趣

视神经脊髓炎谱系疾病（NMOSD）发病机制及实验治疗研究。

三、承担的科研项目

1. 国家自然科学基金面上项目，82602626，星形胶质细胞ERα信号通路介导NMOSD发病性别差异的机制研究，2027-01-01至2029-12-31，30万，在研，主持；

2. 陕西省青年科学基金项目，2026JC-YBQN-0243，补体调节蛋白CD59调控胶质瘤细胞增殖的分子机制及其在肿瘤进展中的作用研究，2026-08-01至2028-07-31，5万，在研，主持。

四、代表性论文

1. Cui T, Gong Y, Wang Z, Li P, Dai L, Chen J, Feng Z, Liu X, Li S, Liu H, Li K, Ding X, Xue X, Yang Y, Zhang L, Li R, Fu Y*, Zhang Y*, Yan Y*. Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes autoimmune astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders. Nat Commun. 2026 May 12;17(1):6348.

2. Cui T#, Wen Q#, An Z#, Kang J, Li P, Zeng Y, Lin L, Gao R, Cheng G, Dai L, Feng Z, Gong Y, Zhang X, Li K, Ding X, Xue X, Yang L, Zhang L, Zhang Y, Yan Y*. Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1-astrocytic integrin alpha4 interaction. PNAS. 2026, 123 (7): e2520566123.

3. Dai L#, Cheng G#, Cui T#, He S, Wang R, Kang J, Li P, Zhang X, Ding X, Xue X, Yang L, Zhang Y*, Yan Y*. Activation status of astrocytes drives the MS/NMOSD therapeutic paradox: Insights from IFNAR1 signaling. Cell Rep. 2026, 45 (2): 116913.

4. He W#, Liu X#, Wang D#, Gong Y, Cui T, Zhang X, Li P, Ding X, Yang L, Zhang Q, Yang Y, Xue X, Shi L*, Zhang Y*, Yan Y*. Post-onset intermittent fasting attenuates neuroinflammation and demyelination via a TRIB3-PERK-autophagy axis in an EAE model of multiple sclerosis. J Neuroinflammation. 2025, 22(1): 301.

5. Yang L#, Hu C#, Chen X#, Sun M#, Zhang J, Feng Z, Cui T, Zhu R, Zhang X, Xiao Y, Gong Y, Yang Y, Zhang Q, Zhang Y, Yan Y*. Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation. J Neuroinflammation. 2025, Apr 30;22(1):126.

6. Qi W#, Han B#, Cui T, Shen P, Zhao Z, Yan Y, Wang L, Lu X, Zhang Y*, Li X*. Intraperitoneal injection but not oral administration of ellagic acid: a novel immunomodulator via targeting casein kinase 2 signaling pathway. Food Science and Human Wellness. 2025, 14:112-122.

7. Yang L#, Hu C#, Chen X#, Zhang J, Feng Z, Xiao Y, He W, Cui T, Zhang X, Yang Y, Zhang Y, Yan Y*. Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis. Elife. 2024, Sep 12;13:RP98181.

8. Zhang Y#, Qu Y#, Song H#, Cheng G, Lu F, Cui T, Gong Y, Ding X, Yang Y, Zhang Q, Yang L, Yan Y*. Isoliquiritigenin alleviates experimental autoimmune encephalomyelitis by modulating inflammatory and neuroprotective reactive astrocytes. Biomed Pharmacother. 2024, Sep;178:117188.

9. Xu L, Ren Y, Wu J, Cui T, Dong R, Huang C, Feng Z, Zhang T, Yang P, Yuan J, Xu X, Liu J, Wang J, Chen W, Mi D, Irwin DM, Yan Y, Xu L, Yu X*, Li G*. Evolution and expression patterns of the neo-sex chromosomes of the crested ibis. Nat Commun. 2024, Feb 23;15(1):1670.

10. Zhu W, Li K, Cui T, Yan Y. Detection of anti-ganglioside antibodies in Guillain-Barré syndrome. Ann Transl Med. 2023, Apr 15;11(7):289.