张娅玲

一、个人简介

张娅玲，女，博士，陕西师范大学生命科学学院副研究员。近年来主要从事神经免疫性疾病的辅助诊断、发病机制与实验治疗研究。先后主持科技部重点研发计划项目子课题1项、国家自然科学基金青年项目1项、陕西省自然科学基金青年项目1项、陕西师范大学“优秀博士学位论文”资助项目1项、横向课题2项，参与国家自然科学基金和陕西省自然科学基金项目8项，参与成果转化1项。目前已发表SCI及核心期刊论文28篇，获得授权发明专利13项。

教育经历

2002.09-2006.07，兰州大学生物技术专业（基地班），学士；

2006.09-2009.07，中国科学院北京基因组研究所遗传学专业，硕士；

2015.09-2018.07，陕西师范大学有机化学专业（有机药物化学方向），博士。

二、主要研究领域及兴趣

神经免疫性疾病的辅助诊断、发病机制与实验治疗研究。

三、主持的科研项目

1. 国家自然科学基金青年项目，新型全人源抗AQP4-ScFv的获得及其治疗AQP-IgG阳性视神经脊髓炎的实验研究，2023/01-2025/12，82201493；

2. 陕西省自然科学基础研究计划项目-一般项目（青年项目），新型嘧啶类化合物的设计合成及抗肿瘤机制，2022/03-2023/12，2022JQ-885；

3. 横向项目，天士力NMO候选分子药效筛选试验，2021/02-2022/12；

4. 横向项目，神经感染疾病体外辅助诊断试剂盒的开发-2，2021/10-2023/12.

四、代表性论文（#第一作者，*通讯作者）

1. Luhang Dai#; Guo Cheng#; Tingting Cui#; Sitong He; Ran Wang; Jingqi Kang; Pei Li; Xin Zhang; Xiaoli Ding; Xiaochang Xue; Luting Yang; Yaling Zhang*; Yaping Yan*. Activation status of astrocytes drives the MS/NMOSD therapeutic paradox: Insights from IFNAR1 signaling, Cell Reports, 2026, 45(2) : 116913.

2. Yaling Zhang#; Xiaoqiang Lv#; Qing Wang#; Xuan Ma; Ruotong Wu; Tingting Cui; Xiaoli Ding; Qian Zhang; Luting Yang; Cungen Ma*; Yaping Yan*. Prior dexamethasone exposure attenuates the therapeutic efficacy of mouse bone marrow-derived mesenchymal stem cells in experimental autoimmune encephalomyelitis by fostering a hostile immunological microenvironment, Journal of Neuroimmunology, 2026, 410: 578814.

3. Weitai He#; Xueli Liu#; Di Wang#; Ye Gong; Tingting Cui; Xin Zhang; Pei Li; Xiaoli Ding; Luting Yang; Qian Zhang; Yang Yang; Xiaochang Xue; Lin Shi*; Yaling Zhang*; Yaping Yan*. Post-onset intermittent fasting attenuates neuroinflammation and demyelination via a TRIB3–PERK–autophagy axis in an EAE model of multiple sclerosis, Journal of Neuroinflammation, 2025, 22 (1): 301.

4. Yaling Zhang#*; Yuan Qu#; Huanhuan Song#; Guo Cheng; Fen Lu; Tingting Cui; Ye Gong; Xiaoli Ding; Yang Yang; Qian Zhang; Luting Yang; Yaping Yan*. Isoliquiritigenin alleviates experimental autoimmune encephalomyelitis by modulating inflammatory and neuroprotective reactive astrocytes, Biomedicine & Pharmacotherapy, 2024, 178: 117188.

5. Ye Gong#; Yaling Zhang#; Zhen Wang; Huanhuan Song; Yuanchu Liu; Aowei Lv; Lili Tian; Wenli Zhu; Ying Fu; Xiaoli Ding; Langjun Cui*; Yaping Yan*. Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis, Journal of Neuroinflammation, 2020, 17(1): 198.

6. Yaling Zhang#; Qiaoli Hou#; Xiabing Li*; Jiuling Zhu; Wei Wang; Baolin Li*; Lijun Zhao; Haibin Xia. Enrichment of novel quinazoline derivatives with high antitumor activity in mitochondria tracked by its self-fluorescence, European journal of medicinal chemistry, 2019, 178: 417-432.

7. Yaling Zhang; Li Chen; Xiabing Li*; Li Gao; Yunxia Hao; Baolin Li*; Yaping Yan. Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor, Journal of enzyme inhibition and medicinal chemistry, 2019, 34(1): 1668-1677.

8. Yaling Zhang; Li Chen; Hongjiang Xu; Xiabing Li*; Lijun Zhao; Wei Wang; Baolin Li*; Xiquan Zhang. 6,7-Dimorpholinoalkoxy quinazoline derivatives as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells, European journal of medicinal chemistry, 2018, 147: 77-89.

五、获奖情况

1. 《视神经脊髓炎谱系疾病的发病机制及实验治疗》，2022年，陕西高等学校科学技术研究优秀成果奖一等奖，第5完成人。