闫亚平

一、个人简介

闫亚平博士，教授，博士生导师。陕西师范大学生命科学学院院长，兼任药用资源与天然药物化学教育部重点实验室主任，陕西省高等学校教学指导委员会药学类副主任委员。主要从事神经免疫、神经感染和神经炎症性疾病的辅助诊断、发病机制与实验治疗研究，致力于该类疾病新的床旁性辅助诊断方法的建立、治疗新靶点的发现等。先后主持国家自然科学基金区域联合重点项目1项、面上和青年等项目6项，国家重点研发计划项目课题1项，参与973计划项目1项。在JAMA Neurology、PNAS、Cell Reports、Molecular Therapy、Journal of Immunology、Elife、J Neuroinflammation、Brain Behavior and Immunity、Neurology N2等杂志上发表100余篇学术论文。申请国家发明专利80件，其中已获授权58件，完成科技成果转化3项；开发神经免疫病辅助诊断试剂盒8大类300余个小项；协助企业获NMPA二类医疗器械注册证3个，CE注册证11个；获省部级科技进步奖二等奖2项；指导本科生获得全国生命科学竞赛国家级一等奖1项、二等奖和三等奖各2项。

二、主要研究领域及兴趣

1. 视神经脊髓炎谱系疾病发病机制与实验治疗；

2. 脱髓鞘疾病髓鞘损伤及修复的机制；

3. 神经免疫病辅助诊断试剂盒的开发。

三、近5年主持的科研项目

1. 国家自然科学基金区域联合重点项目，U25A2066，基于 NMOSD发病机理解析的精准诊疗策略研究，2026/01-2029/12；

2. 国家自然科学基金面上项目，82471381，那他珠单抗加重视神经脊髓炎谱系疾病的机制研究，2025/01-2028/12；

3. 陕西省自然科学基础研究计划项目-杰出青年基金项目，2023-JC-JQ-64，神经免疫病的辅助诊断及实验治疗，2023/01-2025/12；

4. 国家自然科学基金面上项目，82071348，SPARC抑制VEGF/VEGFR信号通路调控星形胶质细胞CD59表达参与NMO中枢特异性病灶形成的机制研究，2021/01-2024/12；

5. 陕西省重点产业创新链（群）项目，2020ZDCYL-SF-009，神经免疫病体外诊断试剂盒的开发与产业化，2020/07-2023/06。

四、代表性论文（#第一作者，*通讯作者）

1. Cui T#, Wen Q#, An Z#, Kang J, Li P, Zeng Y, Lin L, Gao R, Cheng G, Dai L, Feng Z, Gong Y, Zhang X, Li K, Ding X, Xue X, Yang L, Zhang L, Zhang Y, Yan Y*. Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1-astrocytic integrin alpha4 interaction. Proc Natl Acad Sci U S A, 2026, 123 (7): e2520566123.

2. Dai L#, Cheng G#, Cui T#, He S, Wang R, Kang J, Li P, Zhang X, Ding X, Xue X, Yang L, Zhang Y*, Yan Y*. Activation status of astrocytes drives the MS/NMOSD therapeutic paradox: Insights from IFNAR1 signaling. Cell Reports, 2026, 45 (2): 116913.

3. Zhang Y#, Lv X#, Wang Q#, Ma X, Wu R, Cui T, Ding X, Zhang Q, Yang L, Ma C*, Yan Y*. Prior dexamethasone exposure attenuates the therapeutic efficacy of mouse bone marrow-derived mesenchymal stem cells in experimental autoimmune encephalomyelitis by fostering a hostile immunological microenvironment. J Neuroimmunol, 2026, 410: 578814.

4. He W#, Liu X#, Wang D#, Gong Y, Cui T, Zhang X, Li P, Ding X, Yang L, Zhang Q, Yang Y, Xue X, Shi L*, Zhang Y*, Yan Y*. Post-onset intermittent fasting attenuates neuroinflammation and demyelination via a TRIB3–PERK–autophagy axis in an EAE model of multiple sclerosis. J Neuroinflammation, 2025, 22 (1): 301.

5. Yang L#, Hu C#, Chen X#, Sun M #, Zhang J, Feng Z, Cui T, Zhu R, Zhang X, Xiao Y, Gong Y, Yang Y, Zhang Q, Zhang Y, Yan Y*. Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation. J Neuroinflammation, 2025, 22 (1): 126.

6. Yang L#, Hu C, Chen X., Zhang J., Feng Z, Xiao Y, He W, Cui T, Zhang X,Yang Y, Zhang Y, Yan Y*. Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis. Elife, 2024, 13: RP98181.

7. Zhang Y#, Qu Y, Song H, Cheng G, Lu F, Cui T , Gong Y, Ding X, Yang Y, Zhang Q, Yang L, Yan Y*. Isoliquiritigenin alleviates experimental autoimmune encephalomyelitis by modulating inflammatory and neuroprotective reactive astrocytes. Biomed. Pharmacother, 2024, 178, 117188.

8. Zhu W, Li K, Cui T, Yan Y*. Detection of anti-ganglioside antibodies in Guillain-Barre syndrome. Ann Transl Med, 2023, 11 (7), 289.

9. Fu Y#, Bi J#, Yan Y#, Sun X, Li K, Kim S. Y, Han S.-M, Zhou L, Li R, Huang Q, Wang N, Lin A, Kim H. J*, Qiu W*. Rapid Immunodot AQP4 Assay for Neuromyelitis Optica Spectrum Disorder. JAMA Neurol, 2023, 80 (10), 1105-1112.

10. Fu Y*, Zhao W, Lin K, Lv A, Tian L, Wang Z, Li S, Yan Y*. USPIO-SWI shows fingolimod enhanced alteplase action on angiographic reperfusion in eMCAO rats, J. Magn. Reson. Imaging, 2022, 55, 1095-1106.

11. Gong Y, Liu Y, Ding X, Fu Y, Cui L*, Yan Y*. Tanshinone IIA ameliorates CNS autoimmunity by promoting the differentiation of regulatory T cells, Neurotherapeutics. 2020, 17 (2): 690-703.

12. Gong Y#, Zhang Y#, Wang Z, Song H, Liu Y, Lv A, Tian L, Zhu W, Fu Y, Ding X, Cui L*, Yan Y*. Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis. J Neuroinflammation, 2020, 17 (1): 198.

13. Zhu W, Zhang Y, Wang Z, Fu Y, Yan Y*. Monoclonal antibody-based treatments for neuromyelitis optica spectrum disorders: from bench to bedside. Neurosci Bull, 2020, 36 (10): 1213-1224.

14. Zhu W, Wang Z, Hu S, Gong Y, Liu Y, Song H, Ding X, Fu Y, Yan Y*. Human C5-specific single-chain variable fragment ameliorates brain injury in a model of NMOSD. Neurol Neuroimmunol Neuroinflamm, 2019, 6 (3): e561.

15. Wang Z, Guo W, Liu Y, Gong Y, Ding X, Shi K, Thome R, Zhang G, Shi F, Yan Y*. Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes. Brain Behav Immun, 2017, 65:173-182.

五、获奖情况

1. 视神经脊髓炎谱系疾病的发病机制及实验治疗，陕西省科学技术奖自然科学奖二等奖，2023，陕西省人民政府，第一完成人；

2. 中枢神经系统炎性脱髓鞘疾病的免疫学、诊断和治疗研究，天津市科学技术进步奖二等奖，2015，天津市人民政府，第三完成人。