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姓名:董小明

职称/职务:讲师

电话:

传真:

电子信箱:dongxm2008duzhe@126.com

研究方向:功能基因组学与蛋白质组学

办公地点:格物楼3134

 

一、个人简介

2017.10 2018.09  博士后,芬兰,奥卢大学生物化学与分子医学

2013.09 2017.06  博士,天津大学化工学院制药工程专业&北京军事医学科学院放射医学研究所生化与分子生物学研究室

2010.09 2013.06  硕士,北京工业大学生命科学与生物工程学院生物化学与分子生物学专业&北京军事医学科学院放射医学研究所生化与分子生物学研究室

2008.10 2010.09  北京蛋白质组研究中心工作

2004.09 2008.07  本科,延安大学生命科学学院生物技术专业

 

二、主要研究领域及兴趣

转录因子在前列腺癌发生发展中的作用及机制研究

 

三、承担的科研项目

1. 参与国家自然科学基金面上项目,抗肿瘤候选活性化合物L029作用机制研究,2013.1.1-2016.12.31,项目编号:81273543

 

四、代表性论文

1. Dong XM, Liu ED, Meng YX, Liu C, Bi YL, Wu HW, Jin YC, Yao JH, Tang LJ, Wang J, Li M, Zhang C, Yu M, Zhan YQ, Chen H, Ge CH, Yang XM and Li CY. Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination. Scientific Reports. 2016, Sep 2; 6:32710. (IF: 4.259)

2. Dong XM, Yin RH, Yang Y, Feng ZW, Ning HM, Dong L, Zheng WW, Tang LJ, Wang J,Jia YX, Jiang YN, Liu ED, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Yang XM. GATA-2 inhibits Transforming Growth Factor-β signaling pathway through interaction with Smad4. Cell signal. 2014, May, 26(5):1089–1097. (IF: 4.315)

3. Zheng WW*, Dong XM*, Yin RH, Xu FF, Ning HM, Zhang MJ, Xu CWYang Y, Ding YL, Wang ZD, Zhao WB, Tang LJ, Chen H, Wang XH, Zhan YQ, Yu M, Ge CH, Li CY and Yang XM. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cell. 2014, April, 32: 2278-2289. *co-first author (IF: 6.523)

4. Gao P*, Xia JH*, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SPZhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S, The PRACTICAL consortium, Tammela TAuvinen AWang XY, Huang QL, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH. Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus. Cell. 2018 Jul 26;174(3):576-589.

5. Zhao K, Zheng WW, Dong XM, Yin RH, Gao R, Li X, Liu JF, Zhan YQ, Yu M, Chen H, Ge CH, Ning HM, Yang XM, Li CY. EDAG promotes the expansion and survival of human CD34+ cells. PLoS One. 2018 Jan 11;13(1):e0190794.

6. Liu C#, Liu ED#, Meng YX#, Dong XM, Bi YL, Wu HW, Jin YC, Zhao K, Li JJ, Yu M, Zhan YQ, Chen H, Ge CH, Yang XM, Li CY. Keratin 8 reduces colonic permeability and maintains gut microbiota homeostasis, protecting against colitis and colitis-associated tumorigenesis. Oncotarget. 2017 May 27. doi: 10.18632

7. Wang KP, Zhang C, Zhang SG, Liu ED, Dong L, Kong XZ, Cao P, Hu CP, Zhao K, Zhan YQ, Dong XM, Ge CH, Yu M, Chen H, Wang L, Yang XM and Li CY. 3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis. Oxidative Medicine and Cellular Longevity, 2015(3):11-20.

8. Kong XZ, Yin RH, Ning HM, Zheng WW, Dong XM, Yang Y, Xu FF, Li JJ, Zhan YQ, Yu M, Ge CH, Zhang JH, Chen H, Li CY, Yang XM. Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells. PLoS One. 2014, March, 9(3): e91557.

9. Zheng WW, Yang Y, Zhang MJ, Dong XM, Tang LJ, WangXH, Zhan YQ, Yu M, Ge CH, Ning HM, Li CY and Yang XM. Silencing of EDAG induces degradation of NPM1 and sensitivity to chemotherapeutic drug in acute myeloid leukemia patients. Progress in Biochemistry and Biophysics.2013, 40(9): 877~886..

10. 董小明 郑巍薇 尹荣华 詹轶群 杨晓明 李长燕. 利用ChIP-seq技术研究转录因子EDAG在全基因组的结合谱[J]. 中国生物化学与分子生物学报, 2013, 29(6): 578-584.