今天是:
师资队伍
当前位置: 首页 > 师资队伍 > 教学科研人员 > 教授 > 正文

姓名:刘洋

职称/职务:教授

电话:

传真:

电子信箱:yliu@snnu.edu.cn

研究方向:动物分子进化

办公地点:长安校区格物楼2607

 

一、个人简介

2012年毕业于华东师范大学,获博士学位。陕西师范大学生命科学学院教授,博士生导师。多年来一直从事与动物分子进化相关的研究工作,通过基因序列、表达及蛋白功能等多个水平的研究揭示动物适应性进化的分子机制。研究工作主要集中在动物感官(视觉和听觉)和食性进化等方面。已发表学术论文20余篇,其中在PNAS杂志发表论文一篇、Current Biology两篇以及Molecular Biology and Evolution四篇。

 

二、主要研究领域及兴趣

课题组目前的主要研究方向为脊椎动物视觉进化,包括明视觉和暗视觉两方面。脊椎动物的视网膜中具有视锥(cone)和视杆(rod)两类感光细胞,其中视锥细胞与明视觉或称色觉有关,而视杆细胞与暗视觉相关。视锥和视杆细胞中的感光物质是视色素,即视蛋白(opsin)结合生色团。早期脊椎动物具有五种视蛋白,其中四种(SWS1SWS2M/LWSRH2)表达在视锥细胞中行使色觉功能,另外一种rhodopsinRH1)表达在视杆细胞中行使暗视觉。因此,视色素的功能与脊椎动物的视觉直接相关。我们以脊椎动物视色素为对象,研究不同动物类群的色觉和暗视觉能力及其功能演变。通过基因序列分析(基因组大数据)与蛋白功能实验的结合,明确现生物种或远古脊椎动物祖先的视色素表型,进而揭示不同动物类群视觉功能的演化历史及生态学意义,并阐明其分子机理。

 

、代表性论文

1. He C#, Wei Y#, Zhu Y, Xia Y, Irwin DM, Liu Y*. 2019. Adaptive evolution of c-type lysozyme in vampire bats. Journal of Molecular Evolution. 87(9-10): 309-316. (IF = 1.78)

2. Liu Y*, Cui Y, Chi H, Xia Y, Liu H, Rossiter SJ*, Zhang S*. 2019. Scotopic rod vision in tetrapods arose from multiple early adaptive shifts in the rate of retinal release. Proc Natl Acad Sci USA. 116(26): 12627-12628. (IF = 9.58)

3. Li L, Chi H, Liu H, Xia Y, Irwin DM, Zhang S*, Liu Y*. 2018. Retention and losses of ultraviolet-sensitive visual pigments in bats. Scientific Reports. 8:11933. (IF = 4.01)

4. Liu Y*, Chi H, Li L, Rossiter SJ, Zhang S*. 2018. Molecular data support an early shift to an intermediate-light niche in the evolution of mammals. Molecular Biology and Evolution. 35(5): 1130-1134. (IF = 14.8)

5. Yokoyama S*, Tada T, Liu Y, Faggionato D, Altun A. 2016. A simple method for studying the molecular mechanisms of ultraviolet and violet reception in vertebrates. BMC Evolutionary Biology. 16:64. (IF = 3.05)

6. Yokoyama S*, Altun A, Jia H, Yang H, Koyama T, Faggionato D, Liu Y, Starmer WT. 2015. Adaptive evolutionary paths from UV reception to sensing violet light by epistatic interactions. Science Advances. 1: e1500162. (IF = 12.8)

7. Liu Y#, He G#, Xu H, Han X, Jones G, Rossiter SJ*, Zhang S*. 2014. Adaptive functional diversification of lysozyme in insectivorous bats. Molecular Biology and Evolution. 31(11): 2829-2835. (IF = 14.8)

8. Yokoyama S*, Xing J, Liu Y, Faggionato D, Altun A, Starmer WT. 2014. Epistatic adaptive evolution of human color vision. PLoS Genetics. 10(12): e1004884. (IF = 5.22)

9. Yokoyama S*, Starmer WT, Liu Y, Tada T, Britt L. 2014. Extraordinarily low evolutionary rates of short wavelength-sensitive opsin pseudogenes. Gene. 534(1): 93-99. (IF = 2.64)

10. Xu H, Liu Y*, He G, Rossiter SJ, Zhang S*. 2013. Adaptive evolution of tight junction protein claudin-14 in echolocating whales. Gene. 530(2): 208-214. (IF = 2.64)

11. Dong D#*, Lei M#, Liu Y#, Zhang S*. 2013. Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx). BMC Genomics. 14: 916. (IF = 3.5)

12. Pan YH#, Zhang Y#, Cui J, Liu Y, McAllan BM, Liao CC*, Zhang S*. 2013. Adaptation of phenylalanine and tyrosine catabolic pathway to hibernation in bats. PLoS ONE. 8(4): e62039. (IF = 2.78)

13. Xu H, Liu Y, Meng F, He B, Han N, Li G, Rossiter SJ*, Zhang S*. 2013. Multiple bursts of pancreatic ribonuclease gene duplication in insect-eating bats. Gene. 526(2): 112-117. (IF = 2.64)

14. Liu Y#, Xu H#, Yuan X, Rossiter SJ, Zhang S*. 2012. Multiple adaptive losses of alanine-glyoxylate aminotransferase mitochondrial targeting in fruit-eating bats. Molecular Biology and Evolution. 29(6): 1507-1511. (IF = 14.8)

15. Liu Y#, Han N#, Franchini LF#, Xu H, Pisciottano F, Elgoyhen AB, Rajan KE, Zhang S*. 2012. The voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats. Molecular Biology and Evolution. 29(5): 1441-1450. (IF = 14.8)

16. Rossiter SJ*, Zhang S, Liu Y. 2011. Prestin and high frequency hearing in mammals. Communicative & Integrative Biology. 4(2): 236-239.

17. Shen B, Avila-Flores R, Liu Y, Rossiter SJ*, Zhang S*. 2011. Prestin shows divergent evolution between constant frequency echolocating bats. Journal of Molecular Evolution. 73(3): 109-115. (IF = 1.78)

18. Liu Y, Rossiter SJ*, Han X, Cotton JA, Zhang S*. 2010. Cetaceans on a molecular fast track to ultrasonic hearing. Current Biology. 20(20): 1834-1839. (IF = 9.19)

19. Liu Y, Cotton JA*, Shen B, Han X, Rossiter SJ*, Zhang S*. 2010. Convergent sequence evolution between echolocating bats and dolphins. Current Biology. 20(2): R53-R54. (IF = 9.19)

20. Mao X, Liu Y, Zhou Y, He B, Zhang S*. 2009. Development of 19 polymorphic microsatellite loci for the intermediate horseshoe bat, Rhinolophus affinis (Rhinolophidae, Chiroptera). Conservation Genetics. 10(3): 709-711. (IF = 2.28)

21. Liu Y#, Dong D#, Han N, Zhao H, Zhang J, Li G, Racey PA, Zhang S*. 2009. Molecular cloning and evolutionary analysis of hemoglobin alpha-chain genes in bats. Biochemical Genetics. 47(3): 257-265. (IF = 1.93)