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姓名:张媛 

职称/职务:教授

电话:

传真:

电子信箱:yuanzhang@snnu.edu.cn

研究方向:1.中枢神经系统脱髓鞘疾病的发病机制、药物靶点及分子药理

2. 次生代谢调控和药用植物活性成分合成分子机理

办公地点:格物楼3406

 

一、个人简介

张媛,博士,教授,博士生导师。2011年在陕西师范大学获得博士学位,2013-2016年在美国Thomas Jefferson University神经科学系做博士后研究。2011年至今在陕西师范大学药用资源与天然药物化学教育部重点实验室从事教学科研工作。

主要从事中枢神经系统脱髓鞘疾病的发病机制、药物靶点及分子药理的研究工作,先后主持国家自然科学基金2项、科技部项目1项、陕西省自然科学基金3项、陕西省高校科协青年人才托举计划项目1项、中央高校科研项目3项,作为主要完成人参与美国NIH R01项目2项。已发表科研论文60余篇,以第一或通讯作者在本领域国际顶级期刊PNASMolecular TherapyMetabolic EngineeringBrain, Behavior, and ImmunityFrontiers in Immunology等发表研究论文26篇(其中SCI I区论文9篇、II9篇)。申请专利9项,授权1项。2018年入选陕西省青年科技新星。

 

二、主要研究领域及兴趣

1. 髓鞘再生的分子机制

2. 中枢神经系统脱髓鞘疾病的药物筛选

 

、承担的科研项目

1. 国家自然科学基金面上项目,81771345,黄芩苷促进少突胶质前体细胞分化及髓鞘再生的PPARγ/NFIL3信号转导机制,2018/012021/1260万,主持

2. 国家自然科学基金青年科学基金项目,31300256,茉莉酸诱导丹酚酸B合成的COI1-JAZ-MYB75信号转导单元及偶联机制研究,2014/01-2016/1223万,主持

3. 陕西省自然科学基金重点项目,2018JZ3001,茉莉酸诱导丹酚酸合成的JAZ-WD40-61信号转导机制研究,2018/01-2020/1210万,主持

4. 陕西省创新人才推进计划-青年科技新星项目,2019KJXX-022,基于双信号-共培养体系的促髓鞘形成天然药物筛选及其作用机制研究,2019/01-2021/1210万,主持

5. 中央高校基本科研业务费重点项目,GK201802010,雾霾抑制髓鞘形成/再生的TLR-4信号通路研究,2018 /012020/1217万,主持

6. 美国国立卫生研究院NIH/NINDS RO1项目,R01 NS099594Ursolic acid: a novel oral therapy for chronic stage of MS/EAE by both immunomodulation and neural repair美国国立卫生研究院NIH / NINDS项目RO1, R01 NS0995942017/012022/12$1,250,000,第二参与人

7. 美国国立卫生研究院NIH/NINDS RO1项目R01NS07526NSCs produce a triply effective cocktail in the CNS for MS/EAE therapy2012/012017/12$1,250,000第三参与人

 

、代表性论文

1. Zhang Y*, Li X*, Ciric B, Curtis M, Chen WJ, Rostami A, and Zhang GX#. A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination, Proceedings of the National Academy of Sciences of the United States of America, 2020 https://doi.org/10.1073/pnas.2000208117.

2. Lu XY*, Liang XY*, Li X, Shen PX, Cao XY, Chen C, Song SH, Wang DH, Wang ZZ, Zhang Y#. Genome-wide characterisation and expression profling of the LBD family in Salvia miltiorrhiza reveals the function of LBD50 in jasmonate signaling and phenolic biosynthesis, Industrial Crops & Products, 2020; 144:863.

3. Tian J, Cassella G, Zhang Y, Rostami A, Li X#. Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases, International Journal of Biological Sciences, 2020; 16(4):620-632.

4. Tian J*, Li X*, Zhao L*, Shen P, Wang ZZ, Zhu L, Li CQ, Su C, Zhang Y#. Glycyrrhizic Acid Promotes Neural Repair by Directly Driving Functional Remyelination, Food & Function, 2019 29;11:992-1005.

5. Han JJ, Li X, Ye ZQ, Lu XY, Yang T, Tian J, Wang YQ, Zhu L, Wang ZZ, Zhang Y#. Treatment with 6-Gingerol Regulates Dendritic Cell Activity and Ameliorates the Severity of Experimental Autoimmune Encephalomyelitis. Molecular Nutrition & Food Research 2019. doi: 10.1002/mnfr.201801356.SCI 二区;IF= 4.653

6. Zhang Y, Lu XY, Ye ZQ, Ciric B, Ma CG, Rostami A, Li X, Zhang GX. Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination Through a Non-immunomodulatory Mechanism, Frontiers in Cellular Neuroscience, 2019, in press.SCI 二区;IF= 4.300

7. Zhang Y*, Lu XY*, Casella G, Tian J, Ye ZQ, Yang T, Han JJ, Jia LY, Rostami A, Li X. Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells, Frontiers in Cellular Neuroscience, 2019, in press.SCI 二区;IF= 4.300

8. Zhang F*, Zhang Y*, Yang T, Ye ZQ, Tian J, Fang HR, Wang ZZ, Li X. Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling. Frontiers in Pharmacology, 2019; 10:863.SCI 二区;IF= 3.845

9. Wang MR, Zhang XJ, Liu HC, Ma WD, Zhang ML, Zhang Y, Li X, Dou MM, Jing YL, Chu YJ, Zhu L. Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy. Brain Research Bulletin, 2019. doi: 10.1016/j.brainresbull.2019.08.006.

10. Zhang Y*, Han JJ*, Liang XY, Zhao L, Zhang F, Rasouli J, Wang ZZ, Zhang GX, Li X. miR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting CCL7, Molecular Therapy: the journal of the American Society of Gene Therapy. 2018;26(2):582-592.SCI 一区;IF=8.402

11. Zhao L*, Li X*, Ye ZQ, Zhang F, Han JJ, Yang T, Wang ZZ#, Zhang Y#. Nutshell Extracts of Xanthoceras sorbifolia: A New Potential Source of Bioactive Phenolic Compounds as a Natural Antioxidant and Immunomodulator, Journal of Agricultural and Food Chemistry. 2018;66(15):3783-3792. SCI 一区;IF= 3.571

12. Li X, Zhao L, Han JJ, Zhang F, Liu S, Zhu L, Wang ZZ, Zhang GX, Zhang Y#. Carnosol Modulates Th17 cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis, Frontiers in Immunology. 2018; 9:1807-1819.SCI 二区;IF= 5.511

13. Wang LM*, Zhang Y*, Li X*, Zhang ML, Zhu L, Zhang GX, Xu YM. Nr4a1 plays a crucial modulatory role in Th1/Th17 cell responses and CNS autoimmunity. Brain Behavior and Immunity. 2018;68:44-55.SCI 二区;IF=6.306

14. Wu YC*, Zhang Y*, Li L, Guo XR, Wang B, Cao XY, Wang ZZ. AtPAP1 Interacts With and Activates SmbHLH51, a Positive Regulator to Phenolic Acids Biosynthesis in Salvia miltiorrhiza, Frontiers in Plant Science. 2018; 9: 1687-1700.SCI 二区;IF= 3.678

15. 陈尘,曹晓燕,化文平,黄英,刘婷婷,张媛#,王喆之#,基于丹参基因组的 COI1 基因抗虫与次生代谢调控功能研究,中国科学:生命科学,2018;48(4):399-411.IF=3.085

16. Li S, Wu Y, Kuang J, Wang H, Du T, Huang Y, Zhang Y, Cao X, Wang Z. SmMYB111 Is a Key Factor to Phenolic Acid Biosynthesis and Interacts with Both SmTTG1 and SmbHLH51 in Salvia miltiorrhiza, Journal of Agricultural and Food Chemistry. 2018;66(30):8069-8078. SCI 一区;IF=3.412

17. Kang JF, Guo C, Thome R, Yang N, Zhang Y, Li X, Cao X. Hypoglycemic, hypolipidemic and antioxidant effects of iridoid glycosides extracted from Corni fructus: possible involvement of the PI3K-Akt/PKB signaling pathway, RSC Advances. 2018, 8, 30539-30550. SCI 三区;IF=2.936

18. Xie C, Li X, Zhou XJ, Li ZZ, Zhang Y, Zhao L, Hao Y, Zhang GX, Guan YT. TGFb1 transduction enhances immunomodulatory capacity of neural stem cells in experimental autoimmune encephalomyelitis. Brain Behavior and Immunity. 2018;69:283-295. SCI 二区;IF=6.306

19. 韩娟娟,纪砚耘,梁晓燕,张媛,王喆之,李星#,干旱胁迫下丹参数字基因表达谱分析基因组学与应用生物学,2018;7(10):4439-4448.

20. Zhang Y*, Li X*, Ciric B, Ma CG, Gran B, Rostami A, and Zhang GX. Effect of Fingolimod on Neural Stem Cells: A Novel Mechanism and Broadened Application for Neural Repair. Molecular Therapy: the journal of the American Society of Gene Therapy. 2017;25(2):401-15. 第一作者(SCI 一区;IF=8.402

21. Li YH, Xie C, Zhang Y, Li X, Zhang HF, Wang Q, Chai Z, Xiao BG, Thome R, Zhang GX, et al. FSD-C10, a Fasudil derivative, promotes neuroregeneration through indirect and direct mechanisms. Scientific Reports. 2017;7:41227.SCI 三区;IF=4.122

22. Kan QC, Zhang HJ, Zhang Y, Li X, Xu YM, Thome R, Zhang ML, Liu N, Chu YJ, Zhang GX, et al. Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis. Molecular Neurobiology. 2017;54(10):8404-8418SCI 二区;IF=5.076;他引次数:3

23. Li X*, Zhang Y*, Yan Y, Ciric B, Ma CG, Gran B, Curtis M, Rostami A, and Zhang GX. Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity. Molecular Therapy: the journal of the American Society of Gene Therapy. 2016;24(8):1456-69.SCI 一区;IF=8.402

24. Li X*, Zhang Y*, Yan Y, Ciric B, Ma CG, Chin J, Curtis M, Rostami A, and Zhang GX. LINGO-1-Fc-Transduced Neural Stem Cells Are Effective Therapy for Chronic Stage Experimental Autoimmune Encephalomyelitis. Molecular Neurobiology. 2016. 54(6):4365-4378.SCI 二区;IF=5.076

25. Chen C, Zhang Y, Qiakefu K, Zhang X, Han L, Hua W, Yan Y, and Wang Z. Overexpression of tomato Prosystemin (LePS) enhances pest resistance and the production of tanshinones in Salvia miltiorrhiza Bunge. Journal of Agricultural and Food Chemistry. 2016;64 (41) :7760–7769SCI 一区;IF=3.412

26. Zhang Y*, Li X*, Ciric B, Ma CG, Gran B, Rostami A, and Zhang GX. Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway. Scientific Reports. 2015;5:17407. IF=4.122

27. Ge Q*, Zhang Y*, Hua WP, Wu YC, Jin XX, Song SH, and Wang ZZ. Combination of transcriptomic and metabolomic analyses reveals a JAZ repressor in the jasmonate signaling pathway of Salvia miltiorrhiza. Scientific Reports. 2015;5:14048.IF=4.122

28. Ding X*, Yan Y*, Li X*, Li K*, Ciric B, Yang J, Zhang Y, Wu S, Xu H, Chen W, et al. Silencing IFN-gamma binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity. Journal of Immunology. 2015;194(9):4251-64.SCI 二区;IF=4.539

29. Zhang Y, Yan YP, Wu YC, Hua WP, Chen C, Ge Q, and Wang ZZ. Pathway engineering for phenolic acid accumulations in Salvia miltiorrhiza by combinational genetic manipulation. Metabolic Engineering. 2014;21:71-80.SCI 一区;IF=7.674

30. Zhang Y*, Li X*, and Wang Z. Diversity evaluation of Salvia miltiorrhiza using ISSR markers. Biochemical Genetics. 2013;51(9-10):707-21.IF=1.927

31. Zhang Y, Yan YP, and Wang ZZ. The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza. Journal of Agricultural and Food Chemistry. 2010;58(23):12168-75.SCI 一区;IF=3.412

32. Zhang Y, Li X, and Wang Z. Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents. Food and Chemical Toxicology: an international journal published for the British Industrial Biological Research Association. 2010;48(10):2656-62.SCI 二区;IF=3.977;)

33. Zhang Y, and Wang Z. Comparative analysis of essential oil components of two Pinus species from Taibai Mountain in China. Natural Product Communications. 2010;5(8):1295-8.IF=0.809

34. Zhang Y, and Wang ZZ. Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. Comptes Rendus Biologies. 2009;332(9):816-26.IF=1.313

35. Zhang Y, and Wang ZZ. Comparative analysis of essential oil components of three Phlomis species in Qinling Mountains of China. Journal of Pharmaceutical and Biomedical Analysis. 2008;47(1):213-7.IF=2.831

36. Zhang Y, and Wang ZZ. Influence of dring methods on chemical composition of the essential oil of Glechoma Longituba, Chemistry of Natural Compounds, 2007;43:625-628.IF=0.450

37. Wu Y, Liu C, Kuang J, Ge Q, Zhang Y, and Wang Z. Overexpression of SmLEA enhances salt and drought tolerance in Escherichia coli and Salvia miltiorrhiza. Protoplasma. 2014;251(5):1191-9.IF=2.457

38. He M, Wang Y, Hua W, Zhang Y, and Wang Z. De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites. PloS one. 2012;7(7):e42081.IF=2.766

39. Hua WP, Zhang Y, Song J, Zhao LJ, and Wang ZZ. De novo transcriptome sequencing in Salvia miltiorrhiza to identify genes involved in the biosynthesis of active ingredients. Genomics. 2011;98(4):272-9. IF=2.910

40. Kang JF, Zhang Y, Du YL, and Wang ZZ. Chemical composition and antimicrobial activity of the essential oils from Chloranthus japonicus Sieb. and Chloranthus multistachys Pei. Zeitschrift fur Naturforschung C, Journal of biosciences. 2010;65(11-12):660-6. IF=1.528

 

、授权专利

1. 张媛,鹿欣雨,李星,韩娟娟,张菲,赵莉鼠尾草酚在制备防治实验性自身免疫性脑脊髓炎药物的应用,授权公告日:201996日,专利号:201810728002.0,专利申请国:中国。

2. 王喆之,张媛转基因提高丹参中丹酚酸B含量的方法授权公告日:201084日,专利号:ZL 2010 1 0245822.8,专利申请国:中国。

 

、获奖情况

1. 2019年度陕西省青年科技新星,陕西省教育厅。

2. 陕西名优珍稀药材规范化栽培及质量控制研究,陕西省高等学校科学技术奖一等奖,项目编号:17M01,第七完成人。

 

七、学术兼职

1. 项目评审专家:

国家自然科学基金通讯评审专家,教育部学位中心学位论文评审专家、江西省和陕西省科学基金通讯评审专家、中药材基地共建共享联盟专家委员会专家。

2. 会员:

美国免疫学会(American Association of Immunologists)、美国神经病学学会(American Academy of Neurology)、中国细胞生物学学会、陕西省药理学会

3. 审稿人:

担任Acta Pharmaceutica Sinica BScientific ReportsJournal of Agricultural and Food ChemistryInternational Journal of Biological MacromoleculesIndustrial Crops and ProductsSCI期刊审稿人。