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姓名:齐以涛

职称/职务:教授

电话:18792992906

传真:

电子信箱:qiyitao@snnu.edu.cn

研究方向:蛋白质修饰与疾病

办公地点:格物楼2102

一、个人简介

教育经历

1998-2002   山东农业大学   学士  

2002-2007   中国农业大学   博士

工作经历

2007-2012   美国德州心脏研究所 Research assistant

2012 -2014   美国德州心脏研究所 Research associate

2015-至今    陕西师范大学生命科学学院 教授

讲授课程

本科生:细胞生物学、细胞生物学实验、蛋白质工程、细胞信号转导

研究生:高级细胞生物学、高级生物化学与分子生物学、分子细胞生物学、细胞蛋白质研究方法、表观遗传学

科研成果

主要研究蛋白质的SUMO修饰参与发育和疾病发生发展的分子机制,在Mol CellNeuronCell Death DifferJ Biol ChemFASEB J等杂志发表研究论文30余篇,并获得MD Anderson肿瘤中心内科部基础科学类杰出论文奖。研究成果得到了许多国际主流媒体的关注和报道,如ScienceDailyEurekAlert等。已申请专利1项,发表学术著作1部。已获得多项国家和陕西省自然科学基金面上项目的资助。

学术兼职

中国病理生理学会蛋白质修饰与疾病专业委员会委员,中国毒理学会兽医毒理学分会委员,陕西省基因组与健康学会常务理事,陕西省脑疾病细胞分子医学专业委员会委员。Biotechnology letters, Bosnian journal of basic medical sciences, Current proteomics, Molecular and cellular biochemistry等期刊编委,Apoptosis, Breast cancer research and treatment, Cell and bioscience, Food and chemical toxicology等期刊审稿人。

二、主要研究领域及兴趣

SUMO修饰(SUMOylation)是一种和泛素化修饰类似的蛋白质修饰形式,影响其所修饰的蛋白质功能与定位的一个关键性调节机制。它参与调节多种细胞生命活动过程,包括细胞周期、细胞分裂、DNA损伤修复、细胞内转运、调节蛋白稳定和基因转录等。SUMO修饰是一个动态可逆的过程,由SUMO特异的活化酶(E1)、结合酶(E2)和连接酶(E3)相继作用来催化完成,其去SUMO修饰的过程(De-SUMOylation)则是由SUMO特异性蛋白酶家族(SENP)来完成。本实验室主要研究蛋白质的SUMO修饰, 特别是由SENP2介导的去SUMO修饰过程和对细胞信号转导的调控机制,以及它们在发育与疾病过程中的作用与意义。主要研究领域有:

1. SENP2的靶蛋白分子与生物学功能

SENP2的功能是通过对靶蛋白质的去SUMO化,来改变靶蛋白的活性来实现的。因此,研究SENP2的生物学功能,首先要鉴定SENP2的靶蛋白分子。我们通过功能性筛选和基因敲除等策略来寻找和鉴定SENP2的靶蛋白质,并研究SENP2调控靶蛋白的作用与机制,从而来明确SENP2的生物学功能。

2. 调控SENP2的细胞信号网络

SENP2的去SUMO化参与了许多细胞生命活性过程,也会受到细胞信号网络的调控。因此我们在鉴定SENP2靶蛋白的基础上,研究细胞信号通路对这一去SUMO化过程的调节作用与机制,并依此建立SENP2的细胞信号调控网络。

3. SENP2在发育与疾病中的作用与意义

SUMO修饰的靶蛋白分子与发育和疾病有密切的关系,因此SENP2通过这些靶蛋白分子的去SUMO化修饰,必将参与对发育和疾病的调控。我们利用细胞、模式动物及疾病标本,综合运用分子、细胞和发育生物学以及病理学的知识与手段,研究蛋白质的SUMO修饰在发育与疾病过程中的作用机制,为医学实践提供理论基础。

三、承担的科研项目

1. 主持国家自然科学基金面上项目“SUMO特异性蛋白酶3调控小鼠胚胎心脏发育的机制研究818702412019.1-2022.12

2. 主持国家自然科学基金面上项目“SUMO修饰调控Kv7.2/Kv7.3钾离子通道蛋白活性引起癫痫猝死的机制研究816712942017.1-2020.12

3. 主持陕西省自然科学基金面上项目“SUMO修饰影响迷走神经活性引起癫痫猝死的机制研究2017JM30132017.1-2018.12

4. 主持中央高校基本科研业务费专项资金项目“SENP2调控M电流的机制研究,(GK2016030612016.1-2017.12

5. 参与陕西高校青年创新团队项目陕西省特色畜产品安全生产与营养控制创新团队”2019

6. 参与中央高校基本科研业务费创新团队项目细胞凋亡及其清除的分子机制研究GK2017010052017.1-2019.12

7. 参与中央高校基本科研业务费专项资金项目脂酰辅酶A脱氢酶(ACADs)调控三阴性乳腺癌转移的机制研究GK2016030642016.1-2017.12

8. 陕西师范大学引进人才科研启动基本资金项目(2015.1-2018.1

四、代表性论文

2022

1. Yajie Shen, Jingqi Zhou, Kui Nie, Shuhua Cheng, Zhengming Chen, Wenhan Wang, Weiqing Wei, Daiji Jiang, Zijing Peng, Yizhuo Ren, Yirong Zhang, Qiuju Fan, Kristy L. Richards, Yitao Qi, Jinke Cheng, Wayne Tam, Jiao Ma. Oncogenic role of SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2 positive diffuse large B-cell lymphomas. Blood (1TOPIF:22.113). 2022.139(1):73-86.

2021

2. Xu Chen, Yuanyuan Qin, Yuhong Zhang, Xinyi Yang, Zhengcao Xing, Yajie Shen, Jinke Cheng, Edward Yeh, Hongmei Wu, Yitao Qi. SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis. Cell death and differentiation (1TOPIF:15.828 ). 2021: 1-14.

3. Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T.H. Yeh, Hongmei Wu, Yitao Qi. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels. Journal of biological chemistry (2TOPIF:5.157). (2021)297(4): 1-14.

4. Xu Chen, Yuanyuan Qin, Zhenzhen Zhang, Zhengcao Xing, Qiqi Wang, Wenbin Lu, Hong Yuan, Congcong Du, Xinyi Yang, Yajie Shen, Biying Zhao, Huanjie Shao, Xiaotong Wang, Hongmei Wu, Yitao Qi. Hyper-SUMOylation of ERG is essential for the progression of acute myeloid leukemia. Frontiers in molecular biosciences (2区,IF:5.246). 8(2021): 1-15.

5. Yuhong Zhang, Xu Chen, Qiqi Wang, Congcong Du, Wenbin Lu, Hong Yuan, Zhenzhen Zhang, Danqing Li, Xing Ling, Xiang Ren, Yang Zhao, Qi Su, Zhengcao Xing, Yuanyuan Qin, Xinyi Yang, Yajie Shen, Hongmei Wu, Yitao Qi. Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology. Journal of molecular medicine (2区,IF: 4.599). 2021. 99(12): 1797-1813.

6. Congcong Du, Xu Chen, Qi Su, Wenbin Lu, Qiqi Wang, Hong Yuan, Zhenzhen Zhang, Xiaotong Wang, Hongmei Wu, Yitao Qi. The function of SUMOylation and its critical roles in cardiovascular diseases and potential clinical implications. International journal of molecular sciences. (2TOPIF:5.923). 22(2021): 1-22.

7. Biying Zhao, Zhenzhen Zhang, Xu Chen, Yajie Shen, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Shanshan Zhang, Xiaojun Long, Yuhong Zhang, Siming An, Hongmei Wu, Yitao Qi. The important roles of protein SUMOylation in the occurrence and development of leukemia and clinical implications. Journal of cellular physiology (2区,IF:6.384). 236 (2021): 3466-3480.

8. Yuanyuan Qin, Hong Yuan, Xu Chen, Xinyi Yang, Zhengcao Xing, Yajie Shen, Wanying Dong, Siming An, Yitao Qi, Hongmei Wu (*co-correspondence). SUMOylation wrestles with the occurrence and development of breast cancer. Frontiers in oncology (2区,IF:6.244). 11(2021): 1-11.

9. Xu Chen, Yuhong Zhang, Qiqi Wang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Hongmei Wu, Yitao Qi. The function of SUMOylation and its crucial roles in the development of neurological diseases. The FASEB journal (2TOPIF:5.191). 35(4)(2021): 1-17.

10. Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, and Jinke Cheng. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature Communications (1TOPIF: 14.919). (2021)12(1): 4371: 1-14.

11. Hongce Song, Lei Wei, Mingyu Zhong, Xi Chen, Chaoyi Xie, Xiao Chen, Xiaona Wang, Baoyu Huang, Yaqiong Liu, Meiwei Zhang, Yitao Qi, Xiaotong Wang. Ambient ultraviolet B radiation induced valve behavioral acclimation of Pacific oyster which resulted from the different response strategies of smooth and striated adductor muscles. Ecotoxicology and Environmental Safety (2TOPIF:6.291). 228(2021)113035: 1-10.

12. Yaqiong Liu, Kaidi Jin, Baolu Zhang, Qianqian Jin, Zhongqiang Cai, Lei Wei, Xiaomei Wang, Yanxin Zheng, Baoyu Huang, Meiwei Zhang, Yitao Qi, Xiaotong Wang. CRISPR/Cas9 system-mediated gene editing in the Fujian oysters (Crassostrea angulate) by electroporation. Frontiers in marine science (2TOPIF:4.912). 2021: 1-6.

13. 陈徐,赵洋,叶映彤,胡会沂,齐以涛,吴宏梅(并列通讯)。SUMO修饰在神经系统疾病中的作用机制。生命的化学41(5) (2021): 951-963

2020

14. Xiaojun Long, Biying Zhao, Wenbin Lu, Xu Chen, Xinyi Yang, Jifang Huang, Yuhong Zhang, Siming An, Yuanyuan Qin, Zhengcao Xing, Yajie Shen, Hongmei Wu, Yitao Qi. The critical roles of the SUMO-specific protease SENP3 in human diseases and clinical implications. Frontiers in physiology (3区, IF:4.566). 11 (2020): 1-14.

15. 申雅洁,江代纪,彭子京,任逸倬,齐以涛,马皎(并列通讯)。SOX9在肿瘤发生中的作用及调控机制的研究进展。生命科学。32(10) (2020): 1058-1065

16. 邢正操,樊秋菊,吴宏梅。肿瘤干细胞的代谢。中国生物化学与分子生物学报36(9) (2020): 1041-1047

2019

17. Yihong Zhan, Yue Wang, Miao Qi, Panpan Liang, Yu Ma, Ting Li, Hui Li, Congmei Dai, Zhifeng An, Yitao Qi, Hongmei Wu, Huanjie Shao. BH3 mimetic ABT‑263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation. Cell and bioscience (2区,IF:5.026). 2019(9:60):1-18.

2018

18. Xu Chen, Shanshan Zhang, Jifang Huang, Wanying Dong, Hui Xiao, Huanjie Shao, Jinke Cheng, Hongmei Wu, Yitao Qi. Hyper-SUMOylation of K+ channels in sudden unexplained death in epilepsy: Isolation and primary culture of dissociated hippocampal neurons from newborn mice for subcellular localization. Methods in molecular biology. 1684 (2018): 63-71.

19. Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Shao. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical Pharmacology (2区,IF:4.96). 150(2018): 72-85.

2016

20. Hongmei Wu, Xu Chen, Jinke Cheng, Yitao Qi. SUMOylation and Potassium Channels: Links to Epilepsy and Sudden Death. Advances in Protein Chemistry and Structural Biology (3区,IF:3.507). 103 (2016): 295-321.

21. Yi Li, Yitao Qi, Joan Ritho, Yongxin Zhang, Xiaowei Zheng, Jinhui Zhou, Liping Sun. Characterization of flavonoid glycosides from rapeseed bee pollen using a combination of chromatography, spectrometry and nuclear magnetic resonance with a step-wise separation strategy. Natural Product Research (4区,IF:1.999). 2016: 30(2): 228-231.

2015

22. Rong Cai, Jianmin Gu, Haipeng Sun, Xiaobing Liu, Wenhan Mei, Yitao Qi, Song Xue, Shuxun Ren, Joseph E. Rabinowitz, Yibin Wang, Edward T.H. Yeh, Jinke Cheng. Induction of SENP1 in myocardium contributes to abnormalities of mitochondria and cardiomyopathy. Journal of Molecular and Cellular Cardiology (2区,IF:4.133). 79 (2015): 115-122.

23. Jinhui Zhou, Yitao Qi, Joan Ritho, Yongxin Zhang, Xiaowei Zheng, Liming Wu, Yi Li, Liping Sun. Flavonoid glycosides as floral origin markers to discriminate of unifloral bee pollen by LC-MS/MS. Food Control (2区,IF:4.248). 57 (2015): 54-61.

2014

24. Yitao Qi, Jingxiong Wang, Valerie C. Bomben, Depei Li, Shaorui Chen, Hao Sun, Yutao Xi, John G. Reed, Jinke Cheng, Huilin Pan, Jeffrey L. Noebels, Edward T.H. Yeh. Hyper-SUMOylation of the Kv7 potassium channel abolishes the M current leading to seizures and sudden death. Neuron (1TOPIF:17.173). 83(5) (2014): 1159-1171.

25. Yitao Qi, Yong Zuo, Edward T.H. Yeh, Jinke Cheng. SUMO-specific protease 2 is essential for myostatin expression and myogenesis. Journal of Biological Chemistry (2TOPIF:5.157). 289(6) (2014): 3288-3293.

26. Jinhui Zhou, Yitao Qi, Joan Ritho, Lili Duan, Liming Wu, Qingyun Diao, Yi Li, Jing Zhao. Analysis of maltooligosaccharides in honey samples by ultra-performance liquid chromatography coupled with evaporative light scattering detection. Food Research International (2区,IF:3.579). 56 (2014): 260-265.

27. Jinhui Zhou, Yitao Qi, Hongmei Wu, Qingyun Diao, Feifei Tian, Yi Li. Simultaneous determination of trace migration of phthalate esters in honey and royal jelly by gas chromatography with mass spectrometry. Journal of Separation Science (3区,IF:2.741). 37 (2014): 650-657.

2013

28. Jinhui Zhou, Yitao Qi, Qingyun Diao, Liming Wu, Xia Du, Yi Li, Liping Sun. Cytotoxicity of melittin and apamin in human hepatic L02 cells and HepG2 cells in vitro through apoptosis. Toxin reviews (4区,IF:2.851). 32(4) (2013): 60-67.

2011

29. Jinhui Zhou, Yitao Qi, Yali Hou, Jing Zhao, Yi Li, Xiaofeng Xue, Liming Wu, Jinzhen Zhang, Fang Chen. Quantitative determination of juvenile hormone III and 20-hydroxyecdysone in queen larvae and drone pupae of apis mellifera by ultrasonic-assisted extraction and liquid chromatography with electrospray ionization tandem mass spectrometry. Journal of Chromatography B-Analytical Technologies in Biomedical and Life Sciences (3区,IF:2.888). 879 (2011): 2533-2541.

2010

30. Xunlei Kang, Yitao Qi*, Yong Zuo, Qi Wang, Yanqiong Zou, Robert J. Schwartz, Jinke Cheng, Edward T.H. Yeh. (*equal contribution). SUMO-Specific Protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development. Molecular Cell (1TOPIF:17.97). 38 (2010): 191-201.

31. Jinhui Zhou, Jing Zhao, Suxia Zhang, Jianzhong Shen, Yitao Qi, Xiaofeng Xue, Yi Li, Liming Wu, Jinzhen Zhang, Fang Chen, Lanzhen Chen. Quantification of melittin and apamin in bee venom lyophilized powder from Apis mellifera by liquid chromatography-diode array detector-tandem mass spectrometry. Analytical Biochemistry (3区,IF:3.236). 404 (2010): 171-178.

2009

32. Zhiqin Wang, Yitao Qi*, Qian Chen, Di Yang, Shusheng Tang, Xi Jin, Jie Gao, Juanling Fu, Zongcan Zhou, Jie Wang, Xilong Xiao. (*equal contribution). Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells. Toxicology (2区,IF:4.221). 256 (2009): 1-6.

33. 王智琴,齐以涛, 罗红烨,王捷,周宗灿,肖希龙。苯并芘对不同p53 基因型细胞的周期影响。毒理学杂志。23(3) (2009): 205-208

34. 王智琴,齐以涛,杨迪,陈倩,周宗灿,王捷,梁震,肖希龙。苯并芘对HELF细胞周期及相关基因表达的影响。癌变.畸变.突变。21(1) (2009): 42-45

2008

35. Qian Chen, Yiqiang Chen, Yitao Qi, Lihua Hao, Shusheng Tang, Xilong Xiao. Chracterization of carbadox-induced mutagenesis using a shuttle vector pSP189 in mammalian cells. Mutation Research-Fundamental and molecular mechanisms of mutagenesis (4区,IF:2.463). 638 (2008): 11-16.

2007

36. Yitao Qi, Yiding Tu, Di Yang, Qian Chen, Jun Xiao, Yiqiang Chen, Juanling Fu, Xilong Xiao, Zongcan Zhou. Cyclin A but not Cyclin D1 is Essential for c-myc-Modulated Cell Cycle Progression. Journal of cellular physiology (2区,IF:6.384). 210 (2007): 63-71.

37. Di Yang, Yitao Qi, Qian Chen, Zhiqin Wang, Xi Jin, Jie Gao, Juanling Fu, Xilong Xiao, Zongcan Zhou. The over-expression of p53 H179Y residue mutation causes the increase of cyclin A and Cdk4 expression in HELF cells. Molecular and Cellular Biochemistry (3区,IF:2.795). 304 (2007): 219-226.

38. Yiqiang Chen, Yanhong Shang, Xiaoping Wu, Yitao Qi, Xilong Xiao. Enzyme-linked immunosorbent assay for the detection of neomycin in milk: effect of hapten heterology on assay sensitivity. Food and Agricultural Immunology (2区,IF:2.398). 18(2) (2007): 117-128.

39. 杨迪,高杰,齐以涛,陈倩,王智琴,傅娟玲,周宗灿,肖希龙。p53基因对人胚肺成纤维细胞周期影响的研究。癌变.畸变.突变。19(6) (2007): 427-431

2006

40. Xingyuan Cao, Mei Dong, Jianzhong Shen, Beibei Wu, Congming Wu, Xiangdang Du, Zhuo Wang, Yitao Qi, Bingyu Li. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. International Journal of Antimicrobial Agents (2区,IF:4.621). 27 (2006): 431-438.