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姓名:闫亚平

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一、个人简介

闫亚平博士,教授,博士生导师。陕西师范大学生命科学学院副院长,兼任药用资源与天然药物化学教育部重点实验室主任,教育部高等院校药学类教学指导委员会委员。

主要从事神经免疫、神经感染和神经炎症性疾病的辅助诊断、发病机制与实验治疗研究,致力于该类疾病新的床旁性辅助诊断方法的建立、治疗新靶点的发现以及免疫炎症在这类疾病发生发展中的作用等。先后主持国家自然科学基金项目5项,国家重点研发计划项目课题1项,参与973计划项目1项。在Molecular Therapy, Journal of Immunology, Brain, behavior and Immunity, Neurology N2等杂志上发表60余篇学术论文,论文被引2200余次。申请国家发明专利26项,已获授权5项,获省部级科技进步二等奖1项。

 

、承担的科研项目

1. 国家自然科学基金面上项目,82071348SPARC抑制VEGF/VEGFR信号通路调控星形胶质细胞CD59表达参与NMO中枢特异性病灶形成的机制研究,2021/01-2024/1258万元,在研。

2. 国家重点研发计划中医药现代化研究重点专项,2017YFC1701300,山茱萸、黄芩、白及高品质道地中药材规范化种植及精准扶贫示范研究,2018/01-2021/12180万元。在研。

3. 陕西省重点领域创新团队项目,2019TD-043,中药资源保障与开发利用创新团队,2019/07-2022/6100万元。在研。

4. 陕西省重点产业创新链(群)项目,2020ZDCYL-SF-009,神经免疫病体外诊断试剂盒的开发与产业化,2020/07-2023/0680万元。在研。

5. 企业委托研发项目,2019-12,神经感染性疾病体外快速诊断试剂盒的开发,2019/12-2029/11100万元/年。在研。

6. 企业委托研发项目,2019-07,神经系统损伤标志物高灵敏度检测试剂盒的开发,2019/07- 2020/1225万元。在研。

 

、代表性论文

2020:

1. Shu Y, Guo J, Ma X, Yan Y, Wang Y, Chen C, Sun X, Wang H, Yin J, Long Y, Yan X, Lu Z, Petersen F, Yu X, Qiu W. Anti-NMDAR encephalitis is associated with IRF7, BANK1 and TBX21 polymorphisms in two populations. Eur J Neurol, 2020, doi: 10.1111/ene.14596.

2. Liu P, Bai M, Yan X, Ren K, Ding J, Zhao D, Li H, Yan Y, Guo J. Possible coexistence of MOG-IgG-associated disease and anti-Caspr2 antibody-associated autoimmune encephalitis: a first case report. Therapeutic Advances in Neurological Disorders. 2020, 13:1-8.

3. Cui L, Chen J, Zhang X, Yan Y, Li M. First report of damping-off caused by Mucor circinelloides on Aconitum carmichaelii in China. Plant Disease, 2020, doi: 10.1094/PDIS-02-20-0359-PDN.

4. Lv A, Zhang Z, Fu Y, Yan Y, Yang L, Zhu W. Dawson’s fingers in cerebral small vessel disease. Frontiers in Neurology, 2020, 11: 669.

5. Gong Y, Zhang Y, Wang Z, Song H, Liu Y, Lv A, Tian L, Zhu W, Fu Y, Ding X, Cui L, Yan Y*. Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis. Journal of Neuroinflammation, 2020, 17 (1): 198.

6. Zhu W, Zhang Y, Wang Z, Fu Y, Yan Y*. Monoclonal antibody-based treatments for neuromyelitis optica spectrum disorders: from bench to bedside. Neuroscience Bulletin, 2020, 36 (10): 1213-1224.

7. Liu YC, Ma W, Niu JF, Li B, Zhou W, Liu S, Yan Y, Ma J, Wang Z*. Systematic analysis of SmWD40s, and responding of SmWD40-170 to drought stress by regulation of ABA- and H2O2-induced stomal movement in Salvia miltiorrhiza Bunge. Plant Physiol Biochem, 2020, 153: 131-140.

8. Ding J, Ren K, Wu J, Li H, Sun T, Yan Y*, Guo J*. Overlapping syndrome of MOG-IgG-associated disease and autoimmune GFAP astrocytopathy. Journal Neurology, 2020, doi: 10.1007/soo415-020-09869-2.

9. Liu Y, Ma W, Zhou W, Li L, Wang D, Li B, Wang S, Pan Y, Yan Y*, Wang Z*. The cytosolic protein GRP1 facilitates abscisic acid-darkness-induced stomatal closure in Salvia miltiorrhiza. Journal of Plant Physiology, 2020, 245: 153112.

10. Gong Y, Liu YC, Ding XL, Fu Y, Cui LJ, Yan Y*. Tanshinone IIA ameliorates CNS autoimmunity by promoting the differentiation of regulatory T cells. Neurotherapeutics, 2020, 17 (2): 690-703.

2019:

11. Zhang X, Li Y, Feng Z, Zhang Y*, Gong Y, Song H, Ding X, Yan Y*. Multifloroside suppressing proliferation and colony formation, inducing S cell cycle arrest, ROS production, and increasing MMP in human epidermoid carcinoma cell lines A431. Molecules, 2019, 25 (1): 7.

12. Zhu W, Wang Z, Hu S, Gong Y, Liu Y, Song H, Ding X, Fu Y, Yan Y*. A human C5-specific single-chain variable fragment ameliorates brain injury in a model of NMOSD. Neurology: Neuroimmunology & Neuroinflammation, 2019, 6(3): e561.

13. Zhu W, Tian L, Yue X, Liu J, Fu Y, Yan Y*. LncRNA exression profiling of ischemic stroke during the transition from the acute to subcute stage. Frontiers in Neurology, 2019, 10: 36.

14. Tian L, Zhu W, Liu Y, Gong Y, Lv A, Wang Z, Ding X, Li S, Fu Y, Lin Y*, Yan Y*. Neural stem cell transfected with leukemia inhibitory factor promote neuroprotection in a aat model of cerebral ischemia. Neuroscience Bulletin, 2019, 35(5): 901-908.

15. Fang L, Kang X, Wang Z, Wang S, Wang J, Zhou Y, Chen C, Sun X, Yan Y, Kermode AG, Peng L, Qiu W. Myelin oligodendrocyte glycoprotein-IgG contributes to oligodendrocytopathy in the presence of complement, distinct from astrocytopathy induced by AQP4-IgG. Neuroscience Bulletin, 2019, 35 (5): 853-866.

16. Yang C, Yang L, Ma L, Zhang GX, Shi FD, Yan Y, Chang G. Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica. International Journal of Molecular Medicine. 2019, 43 (3): 1395-1405.

17. Zhang Y, Chen L, Li X, Gao L, Hao Y, Li B, Yan Y. Novel 4-arylaminoquinazolines bearing N,N-diethyl (aminoethy) amino moiety with antitumor activity as EGFRwt-TK inhibitor. J Enzyme Inhib Med Chem. 2019, 34 (1): 1668-1677.

2018:

18. Xueying Yu, Bin Chen, Hefei Tang, Wei Li, Ying Fu, Zaiqiang Zhang*, Yaping Yan*. A novel mutation of GARS in Chinese family with distal hereditary motor neuropathy type V; Frontiers in Neurology, 2018: 571.

19.Yu X, Chen B, Tang H, Li W, Fu Y, Zhang Z, Yan Y*. A novel mutation of GARS in a Chinese Family with distal hereditary motor neuropathy type V. Fron Neurol, 2018 9: 571.

20. Chen C, Zhou Y, Wang J, Yan Y, Peng L, Qiu W. Dysregulated microRNA involvement in multiple sclerosis by induction of T helper 1 cell differentiation. Front Immunol, 2018, 9:1256.

21. Fu Y, Yan Y*. Emerging role of immunity in cerebral small vessel disease. Front Immunol, 2018, 9:67.

22. Fang L, Wang Z, Song HH, Zhou YF, Chen C, Yan YP, Qiu W. Hydroxychloroquine fails to attenuate lesion development in a mouse model of neuromyelitis optica. CNS Neurosci Ther, 2018, 24 (9): 842-845.

2017:

23. Wang Z, Yan Y*. Immunopathogenesis in myasthenia gravis and neuromyelitis optica. Front Immunol. 2017, 8:1785.

24. Wen L, Cao X, Han L, Zhao H, Qiu S, Yan Y, Wang X, Chen X, Zheng W, Xu X, Gao Y, Chen Y, Li J, Yang Y, Xu Y. Association of increased Treg and Th17 with pathogenesis of moyamoya disease. Sci Rep. 2017, 7(1): 3071.

25. Wang Z#, Guo W, Liu Y, Gong Y, Ding X, Shi K, Thome R, Zhang GX, Shi FD, Yan Y*. Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes. Brain Behav Immun. 2017, 65: 173-182.

26. Li YH, Yu JW, Xi JY, Yu WB, Liu JC, Wang Q, Song LJ, Feng L, Yan YP, Zhang GX, Xiao BG, Ma CG. Fasudil enhances therapeutic efficacy of neural stem cells in the mouse model of MPTP-induced parkinson’s disease. Molecular Neurobiology, 2017, 54 (7): 5400-5413.

27. Li X#, Zhang Y#, Yan Y#, Ciric B, Ma CG, Chin J, Curtis M, Rostami A, Zhang GX*. LINGO-1-fc-transduced neural stem cells are effective therapy for chronic stage experimental autoimmune encephalomyelitis. Mol Neurobiol, 2017, 54 (6): 4365-4378.

2016:

28. Chen C, Zhang Y, Qiakefu K, Zhang X, Han L, Hu W, Yan Y, Wang Z. Overexpression of tomato prosystemin (LePS) enhances pest resistance and the production of tanshinones in Salvia miltiorrhiza Bunge. Journal of Agricuture and Food Chemistry, 2016, 64 (41): 7760-7769.

29. Shi K#, Wang Z, Liu Y, Gong Y, Fu Y, Hao JW, Shi F-D, Yan Y*. CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders. Journal of Immunology, 2016, 197(9):3471-3480.

30. Zhang CJ#, Gong Y, Zhu W, Qi Y, Yang CS, Fu Y, Chang G, Li Y, Shi S, Wood K, Ladha S, Shi FD, Liu Q, Yan Y*. Augmentation of circulating follicular helper T cells and their impact on autoreactive B cells in Myashenia Gravis. Journal of Immunology, 2016, 197: 2610-2617.

31. Yu JW#, Li YH, Song GB, Yu JZ, Liu CY, Liu JC, Zhang HF, Yang WF, Wang Q, Yan YP, Xiao BG, Ma CG*. Synergistic and superimposed effect of bone marrow-derived mesenchymal stem cells combined with fasudil in experimental autoimmune encephalomyelitis. J Mol Neurosci, 2016. 60 (4): 486-497.

32. Li S#, Yan Y, Jiao Y, Gao Z, Xia Y, Kong L, Yao Y, Tao Z, Song J, Yan Y, Zhang G, Yang J*. Neuroprotective effect of Osthole on neuron synapses in an Alzheimer’s disease cell model via upregulation of microRNA-9. J Mol Neurosci, 2016, 60 (1):71-81.

33. Fu Y#, Yan Y, Qi Y, Yang L, Li T, Zhang N, Yu C, Su L, Zhang R, Shen Y, Lin S, Liu Q, Shao Z, Han Z, Shi FD*. Impact of autologous mesenchymal stem cell infusion on neuromyelitis optica spectrum disorder: a pilot, 2-year observation study. CNS Neurosci Ther, 2016, 22 (8): 677-685.

34. Li X#, Zhang Y#, Yan Y, Ciric B, Ma C-G Gran B, Curtis M, Rostami A, Zhang G-X*. Neural stem cells engineered to express three therapeutic factors mediate recovery from chronic stage CNS autoimmunity. Molecular Therapy, 2016. 24(8): 1456-1469.

35. Yan Y#*, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD*. Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD. Sci China Life Sci. 2016, 59 (12): 1270-1281.

2015:

36. Liu Y, Fu Y, Schoonheim MM, Zhang N, Fan M, Su L, Shen Y, Yan Y, Yang L, Wang Q, Zhang N, Yu C, Barkhof F, Shi FD. Structural MRI substrates of cognitive impairment in neuromyelitis optica. Neurology, 2015, 85: 1491-1499.

37. Li M#, Yan Y*. Experimental models of neuromyelitis optica: current status, challenges and future directions. Neurosci Bull, 2015, 31:735-744.

38. Li YJ#, Chang GQ, Liu Y, Gong Y, Yang C, Wood K, Shi FD, Fu Y*, Yan Y*. Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage. Neurosci Bull, 2015, 31:755-762.

39. Ding X#, Yan Y#, Li X#, Li K#, Ciric B, Yang J, Zhang Y, Wu S, Xu H, Chen W, Lovett-Racke AE, Zhang GX*, Rostami A*. Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity. J Immunol, 2015, 194: 4251-4264.

40. Li YJ#, Zhang F, Qi Y, Chang GQ, Fu Y, Su L, Shen Y, Sun N, Borazanci A, Yang C, Shi FD, Yan Y*. Association of circulating follicular helper T cells with disease course of NMO spectrum disorders. J Neuroimmunol, 2015, 278: 239-46.

2014:

41. Fu Y#, Zhang N, Ren L, Yan Y, Sun N, Li YJ, Han W, Xue R, Liu Q, Hao J, Yu C, Shi FD*. Impact of an immune modulator fingolimod on acute ischemic stroke. Proc Natl Acad Sci U S A. 2014 , 111(51): 18315-20.

42. Kong XD#, Bai S, Chen X, Wei HJ, Jin WN, Li MS, Yan Y, Shi FD*. Alterations of natural killer cells in traumatic brain injury. Neurosci Bull. 2014, 30 (6): 903-12.

43. Fu Y#, Hao J, Zhang N, Ren L, Sun N, Li YJ, Yan Y, Huang D, Yu C, Shi FD*. Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study. JAMA Neurol. 2014, 71(9):1092-101.

44. Kalantari T#, Karimi MH, Ciric B, Yan Y, Rostami A and Kamali-Sarvestani E*. Tolerogenic dendritic cells produced by lentiviral-mediated CD40- and IL-23p19- specific shRNA can ameliorate experimental autoimmune encephalomyelitis by suppressing Th17 cells. Clin Exp Immunol, 2014, 176(2): 180-189.

45. Zhang CJ#, Zhai H, Yan Y, Hao J, Li MS, Jin WN, Su N, Vollmer TL, Shi FD*. Glatiramer acetate ameliorates experimental autoimmune neuritis. Immunol Cell Biol. 2014, 92(2):164-9.

46. Yang J#, Yan Y#, Xia Y, Kang T, Li X, Ciric B, Xu H, Rostami A, Zhang GX*. Neurotrophin 3 Transduction Augments Remyelinating and Immunomodulatory Capacity of Neural Stem Cells. Mol Ther. 2014, 22 (2): 440-50.

2013:

47. Wu S#, Li K, Yan Y, Gran B, Han Y, Zhou F, Guan YT, Rostami A, Zhang GX*. Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis. J Clin Cell Immunol. 2013; 4(3). doi: 10.4172/2155-9899.1000142.

48. Zhang N#, Wen Q, Ren L, Liang W, Xia Y, Zhang X, Zhao D, Sun D, Hu Y, Hao H, Yan Y, Zhang G, Yang J, Kang T*. Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells. Int J Mol Sci. 2013;14(9):18657-69.

49. Yan Y#, Li Z, Zhang GX, Williams MS, Carey GB, Zhang J, Rostami A, Xu H*. Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis. Apoptosis. 2013;18(9):1106-19.

50. Li Y#, Wang Y, Yu L, Sun C, Cheng D, Yu S*, Wang Q, Yan Y, Kang C, Jin S, An T, Shi C, Xu J, Wei C, Liu J, Sun J, Wen Y, Zhao S, Kong Y. miR-146b-5p inhibits glioma migration and invasion by targeting MMP16. Cancer Lett. 2013; 339(2):260-9.

51. Zhang Y#, Yan YP, Wu YC, Hua WP, Chen C, Ge Q, Wang ZZ*. Pathway engineering for phenolic acid accumulations in Salvia miltiorrhiza by combinational genetic manipulation. Metab Eng. 2013; 21C:71-80.

52. Wang Y#, Li Y, Sun J, Wang Q, Sun C, Yan Y, Yu L, Cheng D, An T, Shi C, Xu J, Wei C, Liu J, Wen Y, Zhao S, Li H, Zhang H, Xu H, Yu S*. Tumor-suppressive effects of miR-29c on gliomas. Neuroreport. 2013; 24(12):637-45.

53. Li Z#, Li K, Zhu L, Kan Q, Yan Y, Kumar P, Xu H, Rostami A, Zhang GX*. Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation. BMC Immunol. 2013; 14:20.

2012:

54. Zhang N#, Kang T, Xia Y, Wen Q, Zhang X, Li H, Hu Y, Hao H, Zhao D, Sun D, Yan Y, Zhang GX, Yang J*. Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells. Eur J Pharmacol, 2012, 697 (1-3): 32-39.

55. Zhou F#, Ciric B, Li H, Yan Y, Cullimore M., Safavi F., Zhang G.X., and Rostami AM*. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells. Eur. J. Immunol. 2012, 42 (6): 1449-1458.

56. Yan Y#, Zhang G-X, Williams MS, Carey GB, Rostami AM, and Xu H*. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Molecular Immunology, 2012, 52(2):71-8.

57. Yang J#, Yan Y#, Ciric B, Yu S, Ciric B, Guan Y, Xu H, Rostami AM, Zhang GX*. Acceleraated and enhanced effect of CCR5-transducedbone marrow neural stem cells on autoimmune encephalomyelitis. Acta Neuropathologica, 2012, 124(4):491-503.

58. Yu D#, Corbett B, Yan Y, Zhang GX, Reinhart P, Cho SJ, Chin J*. Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging, 2012, 33(12):2942-2947.

59. Wang ZJ#, Cui LJ, Chen C, Liu XJ, Yan Y, and Wang Z*. Downregulation of Cinnamoyl CoA Reductase affects Lignin and Phenolic Acids Biosynthesis in Salvia miltiorrhiza Bunge. Plant Molecular Biology Reporter2012, 30 (5): 1229-1236.

60. Yan Y#, Ding X#, Li K#, Ciric B., Xu H., Gran B., Rostami A., Zhang G. X*. CNS- specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Molecular Therapy, 2012, 20(7):1338-48.

2011:

61. El-Behi M#, Ciric B#, Dai H, Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A*. The encephalitogenicity of Th17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol. 2011, 12 (6): 568-575.

2010 :

62. Yang J#, Yan Y#, Ciric B, Yu S, Guan Y, Xu H, Rostami AM, Zhang GX*. Evaluation of bone marrow- and brain-derived neural stem cells in therapy of central nervous system autoimmunity. Am. J. Pathol. 2010, 177:1989-2001.

63. Yan Y#, Zhang G X, Cric B, Rostami AM, Xu H*. IDO upregulates Treg cells via tryptophan catabolite and suppresses encephalitogenic T cell responces in EAE. J. Immunol. 2010, 185:5953-61.

64. Xu H#*, Yan Y, Fitzgerald DC, Zhang GX, Rostami AM*. MS4a4B, a CD20 homologue in T cell, inhibits T cell propagation by modulation of cell cycle. PloS One, 2010, Nov 1; 5(11):e13780.

65. Zhang Y#, Yan Y, Wang Z*. The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza. J Agr Food Chem, 2010, 58, 12168-12175.

66. Yan Y#, Wang Z*, Tian W, Dong Z, Spencer SF. Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza. Sci China Life Sci, 2010,53 (2): 273-285.

2007

67. Yan Y#, Wang Z*. Genetic transformation of the medicinal plant Salvia miltiorrhiza by Agrobacterium tumefaciens-mediated method. Plant Cell, Tissue and Organ Culture, 2007, 88: 175-184.